Health Outcomes and Policy Effects (HOPE) Laboratory
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Discover the studies, findings, and perspectives driving innovation in pediatric health – and see how our work informs clinical practice, policy, and outcomes for children.
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Five Keys to Effective Medication Safety at Home
CHLA experts offer tips to help parents protect their children from being harmed by prescription drugs.Children's Hospital Los Angeles has long been a forceful leader on the issue of medication safety, advising parents on what they can do at home to prevent their kids from ingesting prescription drugs that can do them great harm. Effective medication safety requires adhering to a few simple rules. We break those down here with the guidance of Helen Arbogast, DrPH, MPH, Manager of CHLA’s Injury Prevention Program, and CHLA pediatric surgeon Lorraine Kelley-Quon, MD, MSHS, FACS, FAAP, who oversees the Health Outcomes and Policy Effects (HOPE) Laboratory, which devotes a good portion of its research to studying the risks associated with opioid use for infants, children and adolescents. August 1, 2024by Jeff Weinstock Read the full article.
American College of Surgeons: Opioids after Appendectomy Using NSQIP
Dr. Kelley-Quon discusses her recently published article in JACS, Multi-Institutional Quality Improvement Project to Minimize Opioid Prescribing in Children after Appendectomy Using NSQIP-Pediatric. Learn More.
Useful Information:
CHLA Saturday Event Invites Families to Dispose of Unwanted Medications
Prescription drug ‘take-back’ day to focus on protecting kids from ingesting leftover opioid pills. Nothing good can come of having unused and unneeded medications sitting in a household cabinet—and...
CHLA Researchers Find That Length of Opioid Treatment for Hospitalized Infants Differs by Institution and Geography
No existing standard for opioid treatment in critically ill infants Opioids such as fentanyl and morphine can provide effective pain relief for infants with complex medical conditions when used...
Publications
Explore published studies shaping clinical practice and policy.
Lee JS, Kirkpatrick E, Kelley-Quon LI. Advancing advocacy for evidence-based opioid stewardship.– Opens in a new window Semin Pediatr Surg. 2025 Aug 5;35:151524. doi: 10.1016/j.sempedsurg.2025.151524. Epub ahead of print. PMID: 40768922.
Barq RM, Ourshalimian S, Maggo S, Keane OA, Nguyen JQ, Deardorff MA, Lewis T, Lakshmanan A, Mosley SA, Kelley-Quon LI. Opioid-Related Pharmacogenomic Variants in a Retrospective Cohort of High-Risk Hospitalized Infants.– Opens in a new window J Pediatr. 2025 Jul 17:114725. doi: 10.1016/j.jpeds.2025.114725. Epub ahead of print. PMID: 40683459.
Lakshmanan A, Szyman M, Kelley-Quon L; Pediatric Public Policy Council. Supporting the neurodevelopment of newborns exposed to in-hospital opioids.– Opens in a new window Pediatr Res. 2025 Jul 15. doi: 10.1038/s41390-025-04271-y. Epub ahead of print. PMID: 40664783.
Kirkpatrick E, Keane OA, Ourshalimian S, Ing M, Odegard M, Kim E, Kelley-Quon LI. Comparing Provider and Adolescent Estimates of Postoperative Opioid Use.– Opens in a new window J Surg Res. 2025 Jun;310:137-144. doi: 10.1016/j.jss.2025.03.057. Epub 2025 Apr 25. PMID: 40286576; PMCID: PMC12162198.
Odegard MN, Ceasar RC, Obinelo AU, Hijaz DN, Rosales A, Bhanvadia SK, Kirkpatrick M, Kim E, Kelley-Quon LI. Adolescent and Parent Perceptions of the American College of Surgeons Safe and Effective Pain Control Brochure.– Opens in a new window J Pediatr Surg. 2025 Jul;60(7):162331. doi: 10.1016/j.jpedsurg.2025.162331. Epub 2025 Apr 15. PMID: 40246064; PMCID: PMC12170162.
Rook JM, Kelley-Quon LI, Jen HC, Gidwani R. Original Study: Association of High-Deductible Health Plans and Complicated Appendicitis among Children.– Opens in a new window Ann Surg. 2025 Feb 24. doi: 10.1097/SLA.0000000000006680. Epub ahead of print. PMID: 39989359.
Keane OA, Ourshalimian S, Ignacio R, Acker S, Jensen A, Lofberg K, Mueller C, Padilla BE, Pandya S, Rothstein DH, Russell KW, Smith C, O’Guinn M, Ing M, Floan Sachs G, Highet A, Iantorno SE, Templeton LR, Ochoa B, Patwardhan UM, Peace A, Schwab ME, Tran TH, Kelley-Quon LI. Pediatric Cholecystectomy Case Volume and Complexity Following the COVID-19 Pandemic. Pediatrics.– Opens in a new window 2025 Feb 21:e2024068065. doi: 10.1542/peds.2024-068065. Epub ahead of print. PMID: 39978405.
Barq RM, Houshmand L, Keane OA, Ourshalimian S, Kelley-Quon LI. Availability of Prescription Opioid Disposal Bins at United States Children’s Hospitals.– Opens in a new window J Pediatr Clin Pract. 2024 Nov 7;14:200133. doi: 10.1016/j.jpedcp.2024.200133. PMID: 39670085; PMCID: PMC11635014.
Barq RM, Ourshalimian S, Houshmand L, Keane OA, Kim E, Kelley-Quon LI. Evaluating Postoperative Opioid Prescription Fills and Refills for Adolescents Undergoing Surgery.– Opens in a new window J Pediatr Surg. 2025 Feb;60(2):162007. doi: 10.1016/j.jpedsurg.2024.162007. Epub 2024 Oct 30. PMID: 39481296; PMCID: PMC11745920.
Odegard MN, Keane OA, Ourshalimian SA, Russell CJ, Lee WG, O’Guinn ML, Houshmand LMC, Kelley-Quon LI. Clinical outcomes of children with COVID-19 and appendicitis: a propensity score matched analysis.– Opens in a new window Pediatr Surg Int. 2024 Oct 8;40(1):266. doi: 10.1007/s00383-024-05817-7. PMID: 39377975; PMCID: PMC11461633.
Rook JM, Spurrier RG, Russell CJ, Shin CE, Lee SL, Juillard CJ, Kelley-Quon LI. Disparities in Screening for Substance Use Among Injured Adolescents.– Opens in a new window JAMA Netw Open. 2024 Oct 1;7(10):e2436371. doi: 10.1001/jamanetworkopen.2024.36371. PMID: 39365586; PMCID: PMC11452809.
Ing MC, Keane OA, Lakshmanan A, Kim E, Lee HC, Kelley-Quon LI. Opioid equipotency conversions for hospitalized infants: a systematic review.– Opens in a new window J Perinatol. 2024 Sep 20. doi: 10.1038/s41372-024-02121-z. Epub ahead of print. PMID: 39304731.
Keane OA, Ourshalimian S, Kaplan C, Gong C, Lakshmanan A, Hintz S, Lee HC, Ing M, Barq R, Nguyen N, Kelley-Quon LI. The Cost of Opioid Use in High-Risk Hospitalized Infants– Opens in a new window. J Surg Res. 2024 Sep 5;302:825-835. doi: 10.1016/j.jss.2024.07.028. Epub ahead of print. PMID: 39241291.
Odegard M, Keane OA, Ourshalimian SA, Kim E, Kelley-Quon LI. Emergency Abdominal Surgery in Children With COVID-19: A National Surgical Quality Improvement Program-Pediatric Propensity Score Matched Analysis– Opens in a new window. J Surg Res. 2024 Sep;301:439-446. doi: 10.1016/j.jss.2024.06.036. Epub 2024 Jul 20. PMID: 39033594.
Chua KP, Brummett CM, Kelley-Quon LI, Bicket MC, Gunaseelan V, Waljee JF. Pediatric Surgical Opioid Prescribing by Procedure, 2020-2021– Opens in a new window. Pediatrics. 2024 Jul 1;154(1):e2024065814. doi: 10.1542/peds.2024-065814. PMID: 38919985; PMCID: PMC11211692.
Chen SY, Ourshalimian S, Hijaz D, Odegard MN, Kim E, Andras L, Kelley-Quon LI. Opioid consumption before discharge predicts outpatient opioid use in adolescents undergoing surgery– Opens in a new window. Surgery. 2024 Aug;176(2):462-468. doi: 10.1016/j.surg.2024.03.041. Epub 2024 May 19. PMID: 38763792; PMCID: PMC11246811.
Odegard M, Barrington-Trimis J, Keane OA, Ourshalimian S, Kim E, Kelley-Quon LI. Disordered Sleep in Adolescents Recovering From Surgery– Opens in a new window. J Pediatr Surg. 2024 Oct;59(10):161545. doi: 10.1016/j.jpedsurg.2024.03.060. Epub 2024 Apr 4. PMID: 38670831; PMCID: PMC11401771.
Franklin AD, Tsao K, Barq R, Kelley-Quon LI, Veneziano G, Aldrink JH. Updates From the Other Side of the Drape: Recent Advances in Multimodal Pain Management and Opioid Reduction Among Pediatric Surgical Patients– Opens in a new window. J Pediatr Surg. 2024 Jul;59(7):1297-1303. doi: 10.1016/j.jpedsurg.2024.03.027. Epub 2024 Mar 16. PMID: 38614947.
Keane OA, Ourshalimian S, Lakshmanan A, Lee HC, Hintz SR, Nguyen N, Ing MC, Gong CL, Kaplan C, Kelley-Quon LI. Institutional and Regional Variation in Opioid Prescribing for Hospitalized Infants in the US– Opens in a new window. JAMA Netw Open. 2024 Mar 4;7(3):e240555. doi: 10.1001/jamanetworkopen.2024.0555. PMID: 38470421; PMCID: PMC10936113.
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